Krypton 81m ventilation/perfusion ratios (V/Q) measured in lateral decubitus in pulmonary embolism (P. E. )

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6931872

Meignan, M; Cinotti, L; Harf, A; Oliveira, L; Simonneau, G

In normal subjects lateral decubitis induces in both independent (lower) and nondependent lung (upper), major changes in perfusion, ventilation and V/Q ratios which can be studied with the short life radioisotope Krypton 81m. Regional V/Q are computed from ventilation and perfusion scans, successively obtained with a gamma camera linked to a computer by continuous inhalation or infusion of this gas during tidal breathing. They were displayed as a color coded functional image. To assess the effect of posture on V/Q in P.E. and other diseases which decrease the regional perfusion, 32 patients with unilateral lung diseases were studied in supine posture and both lateral decubitis: 8 with proved P.E., (3 out of them having radiological opacity matching the perfusion defect), 9 with bullous emphysema, 6 with bronchogenic carcinoma, 9 with acute bacterial pneumonia. V/Q were computed in the region of the perfusion defect. In P.E. the mean V/Q was high (1.92 +- 0.6 SD), and did not change whatever the posture. Conversely major changes of V/Q were induced with postural changes in bullous emphysema and lung carcinoma whatever the V/Q in patient supine. In pneumonia low V/Q were observed in supine posture (.73 +- .2). They decreased significantly when the pneumonia was dependent (.53 +- .2 p < 0.02) and increased in the controlateral decubitis (1.07 +- .3, p < 0.001). Since posture has no or little effect on regional V/Q in P.E., it can be used to discriminate P.E., even in the case of radiological opacity, from other unilateral disease inducing perfusion defect.

• Research Organization: Dept. of Nuclear Medicine, Hospital Henri Mondor, Creteil 94010
• OSTI ID: 6931872
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
BRONCHI
CAMERAS
CARCINOMAS
COLOR
COMPUTER CALCULATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMBOLI
EMPHYSEMA
EVEN-ODD NUCLEI
GAMMA CAMERAS
IMAGES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LUNGS
NEOPLASMS
NUCLEI
OPACITY
OPTICAL PROPERTIES
ORGANOLEPTIC PROPERTIES
ORGANS
PERFUSED ORGANS
PHYSICAL PROPERTIES
PNEUMONIA
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SECONDS LIVING RADIOISOTOPES
USES
VENTILATION
YEARS LIVING RADIOISOTOPES