Chemical protection against the long-term effects of a single whole-body exposure of mice to ionizing radiation. I. Life shortening. [X radiation]

Journal Article · Fri Jul 01 04:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574717· OSTI ID:7142659

Maisin, J R; Mattelin, G; Lambiet-Collier, M

A systematic study has been made of the advantages gained by treatment with combined radiochemical protectors for long-term survival of mice exposed to a single dose of ionizing radiation. Our results demonstrate that mixtures of radioprotectors increase the degree of protection compared with that obtained with each substance given separately. The dose-effect curves for the long-term survival obtained for irradiated untreated mice and for mice treated with a mixture of radioprotectors are not parallel. Thus the dose-reduction factor (DRF) varies with the X-ray dose administered. The optimum DRF obtained for long-term survival of BALB/c/sup +/ mice (2.5) was very close to that obtained against acute effects of ionizing radiation (2.8).

• Research Organization: CEN/SCK, Mol, Belgium
• OSTI ID: 7142659
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
MICE
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
VERTEBRATES
X RADIATION