Chemical protection against long-term effects of whole-body exposure of mice to ionizing radiation. III. The effects of fractionated exposure to C57Bl mice

Journal Article · Sun Jun 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575315· OSTI ID:5099484

Maisin, J R; Gerber, G B; Lambiet-Collier, M; Mattelin, G

Mice of the C57Bl/Cnb strain were exposed to four fractionated doses delivered at weekly intervals (total doses from 4 x 50 to 4 x 375 R). One group of mice received a mixture of radioprotectors. The animals were followed to their natural death and investigated for histopathology. Life-shortening showed a sigmoid dependency on the dose in nonprotected and protected mice with a dose reduction factor of 2.1 at 50% life-shorteining. Thymic lymphoma was the most predominant cause of death in irradiated C57Bl mice. Radioprotectors diminished significantly the incidence of this disease but apparently did not reduce other causes of death. Reticulum cell sarcoma B also increased at the same low doses as thymic lymphoma. Both thymic lymphoma and reticulum cell sarcoma B increased in frequency after a fractionated dose compared to a single exposure with doses of 600 to 700 R and 300 to 400 R, respectively.

• Research Organization: Centre d'Etude de l'Energie Nucleaire, Mol, Belgium
• OSTI ID: 5099484
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
AMINES
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
CYSTEINE
DEATH
DELAYED RADIATION EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLUTATHIONE
HISTOLOGY
HYDROXY ACIDS
HYDROXYTRYPTOPHAN
IONIZING RADIATIONS
IRRADIATION
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MEA
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGY
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SARCOMAS
THIOLS
THIOUREAS
THYMUS
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION