Prenatal radiation risk to the brain
- Univ. of Arkansas for Medical Sciences, Little Rock (USA)
The Central Nervous System (CNS) exhibits a high sensitivity to ionizing radiation from conception until after birth. X-irradiation damage of the nervous system during development has been well documented and exposure to ionizing radiation above approximately 10 cGy during perinatal development is contraindicated. Shielding of the embryo or fetus usually prevents gross malformations but high energy irradiation of the pregnant female may result in embryonic growth retardation. This may be especially true when the irradiation is coupled with an ethanol-induced reduction in SOD activity. The synergistic interactions between other drugs and ionizing radiation also have been demonstrated. However, the concentration of endogenous compounds such as histamine and serotonin may be increased in the maternal circulation following irradiation and reach the fetal CNS through a blood-brain-barrier that is more permiable than normal. The introduction of histamine and/or serotonin into the fetal circulation may result in fetal hypotension, edema, cerebral ischemia, and damage to the developing CNS. 48 references.
- OSTI ID:
- 7136592
- Journal Information:
- Neurotoxicology (Park Forest South, Illinois); (USA), Vol. 10:3; ISSN 0161-813X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation and pregnancy
Attempt to assess the inheritable effect of methylmercury toxicity subsequent to prenatal exposure of mice
Related Subjects
CENTRAL NERVOUS SYSTEM
SENSITIVITY
IONIZING RADIATIONS
TERATOGENESIS
BLOOD-BRAIN BARRIER
FETUSES
HISTAMINE
PREGNANCY
PRENATAL EXPOSURE
RADIATION HAZARDS
RADIATION INJURIES
REVIEWS
RISK ASSESSMENT
SEROTONIN
SYNERGISM
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOCUMENT TYPES
DRUGS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
INDOLES
INJURIES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRYPTAMINES
560151* - Radiation Effects on Animals- Man