Chemotherapy of cervical carcinoma: use of Tc-99m-MAA infusion to predict drug distribution

Conference · Thu Mar 01 04:00:00 EST 1984 · Radiology; (United States)

OSTI ID:7134652

Kim, E E; Bledin, A G; Kavanagh, J; Haynie, T P; Chuang, V P

Nineteen patients with cervical cancer had infusion of Tc-99m-macroaggregated albumin particles (MAA) via bilateral internal iliac artery catheters to aid in dividing chemotherapeutic dose appropriately between the two catheters. Unequal drug distribution was used to minimize extrapelvic complications (local gluteal burns) by reducing the dose to the side with the greatest gluteal perfusion or to increase the dose to the tumor regions that showed heightened perfusion. Pulmonary uptake, due primarily to arteriovenous shunting in the tumor bed, was seen in all patients. The authors suggest that bulk reduction of locally advanced cervical carcinoma in patients without prior irradiation may be achieved by intra-arterial chemotherapy with tolerable toxicity.

• Research Organization: Univ. of Texas M.D. Anderson Hospital and Tumor Inst., Houston
• OSTI ID: 7134652
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 150:3
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
FEMALE GENITALS
HOURS LIVING RADIOISOTOPES
INFUSION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PELVIS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TISSUE DISTRIBUTION
UTERUS
YEARS LIVING RADIOISOTOPES