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/sup 99m/Tc-labeled macroaggregated albumin in intrahepatic arterial chemotherapy

Journal Article · · AJR, Am. J. Roentgenol.; (United States)
; ; ; ; ; ;

One hundred eighty-four /sup 99m/Tc-labeled macroaggregated albumin (/sup 99m/Tc-MAA) perfusion studies were carried out in 39 patients with histologically proven primary (four) and metastatic (35) hepatic neoplasms. Three different patterns of tumor perfusion were observed: (1) increased central radioactivity (33%); (2) decreased central radioactivity (33%); and (3) mixed and/or diffuse radioactivity (33%). Extrahepatic perfusion as evidenced by radioactive localization in the region of the stomach, pancreas, and small bowel was noted in 51%. Its presence was associated with a higher incidence of gastrointestinal complications (45% vs. 16%). Tumor arteriovenous shunting was demonstrated in 38%, showing localization of radiotracer activity in the lungs, and decreased as tumors decreased in size. The use of /sup 99m/Tc-MAA infusion studies in intrahepatic arterial chemotherapy offers an excellent evaluation of catheter placement and tumor perfusion, in addition to helping to avoid gastrointestinal complications.

Research Organization:
Department of Internal Medicine, Section of Nuclear Medicine, University of Texas System Cancer Center, Houston
OSTI ID:
6584697
Journal Information:
AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 139:4; ISSN AAJRD
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMOTHERAPY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
LUNGS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PERFUSED ORGANS
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
SMALL INTESTINE
STOMACH
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
UPTAKE
YEARS LIVING RADIOISOTOPES