/sup 99m/Tc-labeled macroaggregated albumin in intrahepatic arterial chemotherapy

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.139.4.711· OSTI ID:6584697

Bledin, A G; Kantarjian, H M; Kim, E E; Wallace, S; Chuang, V P; Patt, Y Z; Haynie, T P

One hundred eighty-four /sup 99m/Tc-labeled macroaggregated albumin (/sup 99m/Tc-MAA) perfusion studies were carried out in 39 patients with histologically proven primary (four) and metastatic (35) hepatic neoplasms. Three different patterns of tumor perfusion were observed: (1) increased central radioactivity (33%); (2) decreased central radioactivity (33%); and (3) mixed and/or diffuse radioactivity (33%). Extrahepatic perfusion as evidenced by radioactive localization in the region of the stomach, pancreas, and small bowel was noted in 51%. Its presence was associated with a higher incidence of gastrointestinal complications (45% vs. 16%). Tumor arteriovenous shunting was demonstrated in 38%, showing localization of radiotracer activity in the lungs, and decreased as tumors decreased in size. The use of /sup 99m/Tc-MAA infusion studies in intrahepatic arterial chemotherapy offers an excellent evaluation of catheter placement and tumor perfusion, in addition to helping to avoid gastrointestinal complications.

• Research Organization: Department of Internal Medicine, Section of Nuclear Medicine, University of Texas System Cancer Center, Houston
• OSTI ID: 6584697
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 139:4; ISSN AAJRD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
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