Ocular sensitization of mice by live (but not irradiated) Chlamydia trachomatis serovar A

Journal Article · Wed Oct 01 00:00:00 EDT 1986 · Infect. Immun.; (United States)

OSTI ID:7132982

Colley, D G; Goodman, T G; Barsoum, I S

Ocular exposure of mice to live elementary bodies of Chlamydia trachomatis serovar A results in immunological sensitization of the mice. This reactivity is manifested by the development of early (5 h) and delayed-type (24 h) dermal reactivity and serovar-specific antibody formation against either live or irradiated (100 kilorads) elementary bodies. Parallel ocular exposure of mice to irradiated elementary bodies does not result in this sensitization. The early and late dermal immune responses induced by ocular exposure to live organisms can be transferred to unexposed mice by serum and lymphoid cell transfers, respectively. It appears that successful murine ocular sensitization by human C. trachomatis serovar A elementary bodies is an ability manifested by live organisms and not by inactivated but antigenic organisms.

• Research Organization: Vanderbilt Univ. School of Medicine, Nashville, TN
• OSTI ID: 7132982
• Journal Information: Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 1; ISSN INFIB
• Country of Publication: United States
• Language: English

Related Subjects

560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONJUNCTIVA
CONNECTIVE TISSUE CELLS
EYES
FACE
HEAD
IMMUNE REACTIONS
IMMUNITY
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MEMBRANES
MICE
MICROORGANISMS
MUCOUS MEMBRANES
ORGANS
RODENTS
SENSE ORGANS
SKIN
SOMATIC CELLS
VERTEBRATES