Soluble membrane antigen fractions that react with rat enhancing alloantibodies
Journal Article
·
· Transplantation; (United States)
Soluble extracts were prepared from cells of Brown Norway (BN) rat spleens by sonication in 2 M KI. Extracts were fractionated by gel filtration and electrophoretic procedures. The fractions specifically inhibited the binding of Lewis alloantibodies to target BN cells in vitro and in vivo. A homogeneous component that retained antigen activity was obtained by preparatory polyacrylamide gel electrophoresis. Lewis rats injected with BN antigen fractions produced histocompatibility alloantisera that would prolong the survival of BN skin grafts applied to Lewis neonates.
- Research Organization:
- Scripps Clinic and Research Foundation, La Jolla, CA
- OSTI ID:
- 7126156
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 19:3; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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