Synergistic chemical radiosensitization of hypoxic mammalian cells
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
A combination of two compounds, diamide and nifuroxime, which sensitize hypoxic mammalian cells to x-radiation by different mechanisms, was tested for sensitizing ability in vitro. Concentrations of these agents that did not sensitize hypoxic V79 Chinese hamster cells in vitro when the compounds were present separately during irradiation were extremely effective in reducing survival when they were present together. This result indicates that the combination of diamide plus nifuroxime sensitizes synergistically and suggests that radiosensitization of hypoxic tumor cells in vivo may be possible with much lower drug concentrations than presently required for single agents.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 7118374
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 1:5-6; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
DRUGS
ELECTROMAGNETIC RADIATION
IN VITRO
IONIZING RADIATIONS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
SYNERGISM
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
DRUGS
ELECTROMAGNETIC RADIATION
IN VITRO
IONIZING RADIATIONS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
SYNERGISM
X RADIATION