Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione

Journal Article · Fri Aug 06 00:00:00 EDT 1982 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7089580· OSTI ID:6706007

Bump, E A; Yu, N Y; Brown, J M

Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.

• Research Organization: Department of Radiology, Stanford University Medical Center, CA
• OSTI ID: 6706007
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 217:4559; ISSN SCIEA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL KILLING
CHEMOTHERAPY
DRUGS
ELECTROMAGNETIC RADIATION
GLUTATHIONE
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MISONIDAZOLE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
SYNERGISM
THERAPY
TUMOR CELLS
X RADIATION