Metabolism of arachidonic acid in phorbol ester, interferon and dimethyl sulfoxide differentiation induced U937 cells
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:7117942
U937, a human macrophage cell line can metabolize arachidonic acid to a prostaglandin E2-like substance, and an unidentified lipoxygenase product. This metabolism occurs at very low levels however since these cells have low lipase and fatty acid oxygenase activities. The investigated the appearance of these enzyme activities during differentiation induced by phorbol-12-myristate-13-acetate (PMA), human gamma interferon (INF), and dimethyl sulfoxide (DMSO) on days 1,3 and 5 of stimulation using /sup 3/H-arachidonic acid (/sup 3/H-AA). Culture supernatants were analyzed for free /sup 3/H-AA and /sup 3/H metabolites by radio-thin layer chromatography (/sup 3/H-MET). The increasing percentage of /sup 3/H-AA release suggests the appearance of phospholipase activity during differentiation.
- Research Organization:
- Univ. of Illinois, Chicago
- OSTI ID:
- 7117942
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
CARBOXYLESTERASES
CARBOXYLIC ACIDS
CARCINOGENS
CELL DIFFERENTIATION
CHROMATOGRAPHY
CONNECTIVE TISSUE CELLS
DMSO
ENZYME ACTIVITY
ENZYMES
ESTERASES
ESTERS
GROWTH FACTORS
HYDROLASES
INTERFERON
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPASE
LYMPHOKINES
MACROPHAGES
MAMMALS
MAN
METABOLISM
MITOGENS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PHAGOCYTES
PHORBOL ESTERS
PRIMATES
PROTEINS
SEPARATION PROCESSES
SOMATIC CELLS
SULFOXIDES
THIN-LAYER CHROMATOGRAPHY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
CARBOXYLESTERASES
CARBOXYLIC ACIDS
CARCINOGENS
CELL DIFFERENTIATION
CHROMATOGRAPHY
CONNECTIVE TISSUE CELLS
DMSO
ENZYME ACTIVITY
ENZYMES
ESTERASES
ESTERS
GROWTH FACTORS
HYDROLASES
INTERFERON
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPASE
LYMPHOKINES
MACROPHAGES
MAMMALS
MAN
METABOLISM
MITOGENS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PHAGOCYTES
PHORBOL ESTERS
PRIMATES
PROTEINS
SEPARATION PROCESSES
SOMATIC CELLS
SULFOXIDES
THIN-LAYER CHROMATOGRAPHY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES