Preparation of radiopharmaceuticals labeled with metal radionuclides

Technical Report · Mon Jun 01 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/7114628· OSTI ID:7114628

Welch, M J

We recently developed a useful zinc-62/copper-62 generator and are presently evaluating copper-62 radiopharmaceuticals for clinical studies. While developing these copper-62 radiopharmaceuticals, in collaboration with the University of Missouri Research Reactor, Columbia we have also explored copper-64 radiopharmaceuticals. The PET images we obtained with copper-64 tracers were of such high quality that we have developed and evaluated copper-64 labeled antibodies for PET imaging. The major research activities described herein include: the development and assessment of gallium-68 radiopharmaceuticals; the development and evaluation of a new zinc-62/copper-62 generator and the assessment of copper-62 radiopharmaceuticals; mechanistic studies on proteins labeled with metal radionuclides.

• Research Organization: Washington Univ., St. Louis, MO (United States). Edward Mallinckrodt Inst. of Radiology
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60512
• OSTI ID: 7114628
• Report Number(s): DOE/ER/60512-6; ON: DE92017304
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COPPER 62
COPPER 64
COPPER ISOTOPES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 68
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIPIDS
LIPOPROTEINS
MAMMALS
METALLOPROTEINS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PERFORMANCE
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
PROTEINS
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
TOMOGRAPHY
TRANSFERRIN
VERTEBRATES