Preparation of radiopharmaceuticals labeled with metal radionuclides. Progress report, July 1, 1988--June 30, 1992

Technical Report · Mon Jun 01 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/10161051· OSTI ID:10161051

Welch, M J

We recently developed a useful zinc-62/copper-62 generator and are presently evaluating copper-62 radiopharmaceuticals for clinical studies. While developing these copper-62 radiopharmaceuticals, in collaboration with the University of Missouri Research Reactor, Columbia we have also explored copper-64 radiopharmaceuticals. The PET images we obtained with copper-64 tracers were of such high quality that we have developed and evaluated copper-64 labeled antibodies for PET imaging. The major research activities described herein include: the development and assessment of gallium-68 radiopharmaceuticals; the development and evaluation of a new zinc-62/copper-62 generator and the assessment of copper-62 radiopharmaceuticals; mechanistic studies on proteins labeled with metal radionuclides.

• Research Organization: Washington Univ., St. Louis, MO (United States). Edward Mallinckrodt Inst. of Radiology
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60512
• OSTI ID: 10161051
• Report Number(s): DOE/ER/60512--6; ON: DE92017304
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703
550601
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
COPPER 62
COPPER 64
GALLIUM 68
LABELLING
LIPOPROTEINS
MYOCARDIUM
PATIENTS
PERFORMANCE
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
PROTEINS
RADIOISOTOPE GENERATORS
RADIOISOTOPE PRODUCTION
RADIOPHARMACEUTICALS
RATS
SCINTISCANNING
TRANSFERRIN
UNSEALED RADIONUCLIDES IN DIAGNOSTICS