Graft-versus-host reaction-like phenomenon induced by BCG in mice lethally irradiated and transferred with syngeneic bone marrow cells. [X Radiation, Bacillus Calmette-Guerin]
Journal Article
·
· Cell. Immunol.; (United States)
Heat-killed BCG in paraffin exerted a lethal effect on C57BL/6 mice irradiated lethally and transferred with syngeneic bone marrow cells. Such an effect was not detectable when mice were subjected to adult thymectomy and used as the hosts. Lymphoid cells from such nonthymectomized mice exhibited cytotoxicity to syngeneic tumor cells but not to allogeneic tumor cells in an in vivo cytotoxicity test and induced splenomegaly in sublethally irradiated syngeneic recipients after systemic transfer. The cytotoxicity of such lymphoid cells was abolished by a treatment with anti-theta serum and complement. In the bone marrow of mice irradiated and transferred with bone marrow cells, the number of nucleated cells, the ratio of mycloid to erythroid cell series, and the percentage of lymphocytes were increased by BCG injection. These results suggest the possibility that self-tolerance may be broken by BCG injection. These results suggest the possibility that self-tolerance may be broken by BCG stimulation in the process of reconstitution of lymphoid cells in the irradiated mice.
- Research Organization:
- Kyushu Univ., Fukuoka, Japan
- OSTI ID:
- 7110131
- Journal Information:
- Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 29:2; ISSN CLIMB
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Effect of selective T cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10. D2----B10)
The nature of tolerance in adult recipient mice made tolerant of alloantigens with supralethal irradiation followed by syngeneic bone marrow cell transplantation plus injection of F1 spleen cells
Thesis/Dissertation
·
Wed Dec 31 23:00:00 EST 1980
·
OSTI ID:5334480
Effect of selective T cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10. D2----B10)
Journal Article
·
Tue Dec 31 23:00:00 EST 1985
· J. Immunol.; (United States)
·
OSTI ID:5675323
The nature of tolerance in adult recipient mice made tolerant of alloantigens with supralethal irradiation followed by syngeneic bone marrow cell transplantation plus injection of F1 spleen cells
Journal Article
·
Thu Jun 01 00:00:00 EDT 1989
· Transplantation; (USA)
·
OSTI ID:5560167
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACILLUS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
HEAT TREATMENTS
IMMUNE REACTIONS
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SURGERY
THYMECTOMY
TOXICITY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACILLUS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
HEAT TREATMENTS
IMMUNE REACTIONS
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SURGERY
THYMECTOMY
TOXICITY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
X RADIATION