Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Studies are presented demonstrating inhibition of both insulin and phorbol myristate acetate stimulated uptake of 2-deoxyglucose uptake by 3T3-L1 fibroblasts. Greatest inhibition of uptake was seen with sphinganine while sphingosine was also potent in this regard. Ceramide inhibited phorbol myristate acetate but not insulin stimulation of uptake. It is suggested that sphingolipid inhibition of glucose transport relates to the previously demonstrated effect of corticosteroids to increase membrane sphingomyelin and inhibit glucose transport.
- Research Organization:
- Univ. of Utah School of Medicine, Salt Lake City
- OSTI ID:
- 7107142
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 138:1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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OSTI ID:5202871
Related Subjects
550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARCINOGENS
CONNECTIVE TISSUE CELLS
DATA
ESTERS
EXPERIMENTAL DATA
FIBROBLASTS
GLUCOSE
HEXOSES
HORMONES
INFORMATION
INHIBITION
INSULIN
KINETICS
LIPIDS
MONOSACCHARIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
PHORBOL ESTERS
PHOSPHOLIPIDS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
SACCHARIDES
SOMATIC CELLS
SPHINGOMYELINS
STIMULATION
UPTAKE
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARCINOGENS
CONNECTIVE TISSUE CELLS
DATA
ESTERS
EXPERIMENTAL DATA
FIBROBLASTS
GLUCOSE
HEXOSES
HORMONES
INFORMATION
INHIBITION
INSULIN
KINETICS
LIPIDS
MONOSACCHARIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
PHORBOL ESTERS
PHOSPHOLIPIDS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
SACCHARIDES
SOMATIC CELLS
SPHINGOMYELINS
STIMULATION
UPTAKE