Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Studies are presented demonstrating inhibition of both insulin and phorbol myristate acetate stimulated uptake of 2-deoxyglucose uptake by 3T3-L1 fibroblasts. Greatest inhibition of uptake was seen with sphinganine while sphingosine was also potent in this regard. Ceramide inhibited phorbol myristate acetate but not insulin stimulation of uptake. It is suggested that sphingolipid inhibition of glucose transport relates to the previously demonstrated effect of corticosteroids to increase membrane sphingomyelin and inhibit glucose transport.
- Research Organization:
- Univ. of Utah School of Medicine, Salt Lake City
- OSTI ID:
- 7107142
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Vol. 138:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
BIOCHEMICAL REACTION KINETICS
INSULIN
BIOLOGICAL EFFECTS
PHORBOL ESTERS
SPHINGOMYELINS
RESPONSE MODIFYING FACTORS
EXPERIMENTAL DATA
FIBROBLASTS
INHIBITION
PHOSPHOLIPIDS
STIMULATION
UPTAKE
ALDEHYDES
ANIMAL CELLS
CARBOHYDRATES
CARCINOGENS
CONNECTIVE TISSUE CELLS
DATA
ESTERS
HEXOSES
HORMONES
INFORMATION
KINETICS
LIPIDS
MONOSACCHARIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
REACTION KINETICS
SACCHARIDES
SOMATIC CELLS
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry
59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
BIOCHEMICAL REACTION KINETICS
INSULIN
BIOLOGICAL EFFECTS
PHORBOL ESTERS
SPHINGOMYELINS
RESPONSE MODIFYING FACTORS
EXPERIMENTAL DATA
FIBROBLASTS
INHIBITION
PHOSPHOLIPIDS
STIMULATION
UPTAKE
ALDEHYDES
ANIMAL CELLS
CARBOHYDRATES
CARCINOGENS
CONNECTIVE TISSUE CELLS
DATA
ESTERS
HEXOSES
HORMONES
INFORMATION
KINETICS
LIPIDS
MONOSACCHARIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
REACTION KINETICS
SACCHARIDES
SOMATIC CELLS
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry