Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: Studies with hydrogen peroxide and phorbol ester
Journal Article
·
· Life Sciences; (USA)
- Univ. of Utah School of Medicine, Salt Lake City (USA)
The mechanism of the inhibitory action of glucocorticoids on glucose uptake is incompletely understood. Treatment with corticosteriods of cells in which glucose uptake is stimulated at insulin postbinding and postreceptor sites may clarify the site of the steroid inhibitory action. Hydrogen peroxide, which has been shown to stimulate the insulin receptor tyrosine kinase, and phorbol myristate acetate (PMA) which stimulates protein kinase C were, therefore, used as stimulators of glucose transport in this study. These studies demonstrate that dexamethasone and the sphingoid bases, sphinganine and sphingosine, inhibit glucose uptake that has been stimulated at either the receptor kinase or protein kinase C level in both 3T3-L1 and 3T3-C2 cells. These data confirm glucocorticoid inhibitory action at a post binding level and support the suggestion that some corticosteriod inhibitory effects may be mediated by an action on sphingolipid metabolism.
- OSTI ID:
- 6695426
- Journal Information:
- Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 46:25; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALDEHYDES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARCINOGENS
CORTICOSTEROIDS
DEXAMETHASONE
ENZYMES
ESTERS
GLUCOCORTICOIDS
GLUCOSE
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXY COMPOUNDS
INHIBITION
INSULIN
KETONES
KINETICS
MEMBRANE PROTEINS
MONOSACCHARIDES
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEROXIDES
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PREGNANES
PROTEINS
REACTION KINETICS
RECEPTORS
SACCHARIDES
STEROIDS
TRANSFERASES
UPTAKE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALDEHYDES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARCINOGENS
CORTICOSTEROIDS
DEXAMETHASONE
ENZYMES
ESTERS
GLUCOCORTICOIDS
GLUCOSE
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXY COMPOUNDS
INHIBITION
INSULIN
KETONES
KINETICS
MEMBRANE PROTEINS
MONOSACCHARIDES
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEROXIDES
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PREGNANES
PROTEINS
REACTION KINETICS
RECEPTORS
SACCHARIDES
STEROIDS
TRANSFERASES
UPTAKE