Mouse chromosome translocations: visualization and analysis by electron microscopy of synaptonemal complex
Journal Article
·
· Science; (United States)
- Duke Univ. Medical Center, Durham, NC
Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurements agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is in the pairing region of the X.
- OSTI ID:
- 7107037
- Journal Information:
- Science; (United States), Journal Name: Science; (United States) Vol. 196:4292; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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