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Identification of aberrant chromosomes on the basis of morphometry of synaptonemal complexes in the sterile male mouse

Journal Article · · Sov. Genet. (Engl. Transl.); (United States)
OSTI ID:6036704
; ;
The results of an investigation of the synaptonemal complexes (SCs) of spermatocytes of sterile males of the house mouse from the progeny of parents subjected to the action of a mutagen are presented in this study. A nonreciprocal translocation was readily identified by the configuration of the SCs. The translocation was observed at pachytene in 100% of cells; at diakinesis-metaphase I, in 58% of cells. A different pattern of association of the X chromosome with the rearrangement region was found in pachytene spermatocytes. Computer analysis of the relative lengths of the synaptonemal complex during the pachytene stage permitted the determination that the translocation took place from the 4th autosome to the 16th. The translocated segment was 66-75% of chromosome 4. In chromosome 16 the point of rupture is close to the distal end, and it was not possible to find the broken-off telomeric fragment of this chromosome in the male under study.
Research Organization:
N.I. Vavilov Institute of General Genetics, Moscow (USSR)
OSTI ID:
6036704
Journal Information:
Sov. Genet. (Engl. Transl.); (United States), Journal Name: Sov. Genet. (Engl. Transl.); (United States) Vol. 24:7; ISSN SOGEB
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
550400* -- Genetics
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CELL CONSTITUENTS
CELL DIVISION
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
CHROMOSOMES
COMPUTER CALCULATIONS
DIMENSIONS
ELECTRON MICROSCOPY
GENETIC EFFECTS
GERM CELLS
HETEROCHROMOSOMES
LENGTH
MALES
MAMMALS
MICE
MICROSCOPY
MITOSIS
MOLECULAR STRUCTURE
MUTAGENS
MUTATIONS
PROGENY
RODENTS
SPERMATOCYTES
STERILITY
VERTEBRATES
X CHROMOSOME