The effect of dietary sulfur on the metabolism of long chain polyunsaturated fatty acids
Thesis/Dissertation
·
OSTI ID:7105575
The effect of methionine-supplemented diet on the metabolism of polyunsaturated fatty acids was studied by comparing results of control and cysteine-supplemented diets in rats. Adult Sprague-Dawley rats were fed for a period of 17 days one of the following diets: control, cysteine-supplemented, and/or methionine-supplemented. On the last day of the feeding period, the rats were administered either (1-{sup 14}C) arachidonic acid (AA) or (1-{sup 14}C) eicosapentaenoic acid (EPA) by stomach tube five hours before sacrificing. The cyclooxygenase activity in liver microsomes, the apparent Km of the fatty acyl-CoA synthetase in liver and brain homogenates, and the incorporation of polyunsaturated fatty acids into the phosphatidylinositol fraction of brain, heat, lung, spleen, and kidney tissues were analyzed.
- Research Organization:
- Teledyne Brown Engineering, Huntsville, AL (USA)
- OSTI ID:
- 7105575
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CYSTEINE
DIET
DISTRIBUTION
DRUGS
EICOSANOIC ACID
ENZYME ACTIVITY
ENZYMES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIGASES
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
METHIONINE
MICROSOMES
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
OXIDOREDUCTASES
OXYGENASES
RATS
RIBOSOMES
RODENTS
THIOLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CYSTEINE
DIET
DISTRIBUTION
DRUGS
EICOSANOIC ACID
ENZYME ACTIVITY
ENZYMES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIGASES
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
METHIONINE
MICROSOMES
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
OXIDOREDUCTASES
OXYGENASES
RATS
RIBOSOMES
RODENTS
THIOLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES