Activation of polyunsaturated fatty acids by rat tissues in vitro
The conversion of labeled palmitic, linoleic, arachidonic and docosahexaenoic acids to their respective acyl CoA's was studied in homogenates and microsomes of rat tissues. The highest activity, both in homogenates and microsomes, was seen in liver and heart. There was moderate activity in retina, brain, lung, kidney and testes and the lowest activity was found in spleen. Docosahexaenoic acid was activated much less actively in heart tissue than the other fatty acids. In all tissues examined, the highest activation was observed with arachidonic acid and the lowest with docosahexaenoic acid. Except for liver, those tissues that contained high levels of docosahexaenoic acid also had the highest activation capacity for this fatty acid.
- Research Organization:
- Louisiana State Univ. Medical Center School of Medicine, New Orleans
- OSTI ID:
- 5558430
- Journal Information:
- Lipids; (United States), Journal Name: Lipids; (United States) Vol. 19:12; ISSN LPDSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARACHIDONIC ACID
BODY
BODY AREAS
BRAIN
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
COENZYMES
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
EYES
FACE
GLANDS
GONADS
HEAD
HEART
HEXADECANOIC ACID
HEXANOIC ACID
HOMOGENATES
IN VITRO
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LINOLEIC ACID
LIVER
LUNGS
MALE GENITALS
MAMMALS
METABOLIC ACTIVATION
MICROSOMES
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RETINA
RODENTS
SENSE ORGANS
SPLEEN
TESTES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARACHIDONIC ACID
BODY
BODY AREAS
BRAIN
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
COENZYMES
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
EYES
FACE
GLANDS
GONADS
HEAD
HEART
HEXADECANOIC ACID
HEXANOIC ACID
HOMOGENATES
IN VITRO
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LINOLEIC ACID
LIVER
LUNGS
MALE GENITALS
MAMMALS
METABOLIC ACTIVATION
MICROSOMES
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RETINA
RODENTS
SENSE ORGANS
SPLEEN
TESTES
VERTEBRATES