A TaqI RFLP detected by the human haptoglobin (HP) cDNA probe, pULB1148

Journal Article · Thu Aug 25 04:00:00 EDT 1988 · Nucleic Acids Research; (UK)

DOI:https://doi.org/10.1093/nar/16.16.8203· OSTI ID:7100823

Hyland, V J ^[1]

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1. Adelaide Children's Hospital, North Adelaide (Australia)

pULB1148 has a 1.4 kb HP cDNA insert in the PstI site of pBR322 (Straten, A. et al., 1983). TaqI identifies an invariant band of 7.0 kb and a simple two allele polymorphism with a band of either 7.2 kb (F.1) or 5.8 kb (F.2). The haptoglobin gene has been localized to 16q22.105->16q22.108 by Southern blot analysis of human-mouse cell hybrids. Co-dominant inheritance was shown in the three generation Utah pedigree K-1331. The three generation family is shown below. The following haplotype frequencies were observed among 25 unrelated Utah individuals: C.1/F.1 0.14, C.1/F.2 0.4 and C.2/F.1 0.46. No C.2/F.2 haplotype was detected.

• OSTI ID: 7100823
• Journal Information: Nucleic Acids Research; (UK), Journal Name: Nucleic Acids Research; (UK) Vol. 16:16; ISSN 0305-1048; ISSN NARHA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
CELL CONSTITUENTS
CHROMOSOMES
DNA
DNA HYBRIDIZATION
DNA SEQUENCING
ELECTROPHORESIS
GENES
GENETIC MAPPING
GLOBIN
HETEROCHROMOSOMES
HUMAN POPULATIONS
HYBRIDIZATION
MAPPING
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLASMIDS
POPULATIONS
RECOMBINANT DNA
RFLPS
STRUCTURAL CHEMICAL ANALYSIS