Effects of some tobacco smoke constituents on foreign compound metabolism in the cat and the rat

Journal Article · Tue Mar 01 04:00:00 EST 1977 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:7097959

Turner, D M

The effects of chronic nicotine administration on its own metabolism have been studied in the cat and the rat. Nicotine administration caused an increase in the in vitro metabolism in the liver of both species and in cat kidney. Cotinine production from nicotine was enhanced in both species by pretreatment with nicotine. The magnitude of the increase in enzyme activity was relatively small but of the same order as that produced, in the rat, by phenobarbital treatment. 3-methylcholanthrene pretreatment stimulated rat liver nicotine metabolism but was without effect on cotinine production. Chronic exposure of rats to relatively low levels of carbon monoxide inhibited the in vitro aryl hydrocarbon hydroxylase activity but did not affect nicotine metabolism. The data are discussed in relation to the observed enzyme inductive effects of tobacco smoke.

• Research Organization: Hazelton Labs. Europe Ltd., Harrogate, Eng.
• OSTI ID: 7097959
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 16:3; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKALOIDS
AMINES
ANIMALS
AROMATICS
ARYL RADICALS
AZINES
AZOLES
BARBITURATES
BIOLOGICAL EFFECTS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CATS
CHALCOGENIDES
CHOLANTHRENE
CHRONIC INTAKE
COLLOIDS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISPERSIONS
DRUGS
ENZYMES
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYPNOTICS AND SEDATIVES
IN VITRO
INTAKE
KIDNEYS
LIVER
MAMMALS
METABOLISM
NICOTINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHENOBARBITAL
PYRIDINES
PYRIMIDINES
PYRROLES
PYRROLIDINES
RADICALS
RATS
RESIDUES
RODENTS
SMOKES
SOLS
STIMULATION
TOBACCO SMOKES
VERTEBRATES