Development of the septal region in the rat. II. Morphogenesis in normal and x-irradiated embryos

Journal Article · Mon Jan 01 04:00:00 EST 1979 · J. Comp. Neurol.; (United States)

DOI:https://doi.org/10.1002/cne.901830109· OSTI ID:7097764

Bayer, S A

Morphogenesis of the septal region was examined in normal rat embryos from embryonic day (E) 10 to E22. The greater part of the septal region is postulated to form from two separate anlagen which can be clearly distinguished in the telencephalon by E13 and E14. One lies in the anterior ventromedial wall and presumably forms the nucleus of the diagonal band, medial, lateral, and triangular septal nuclei. The other lies in the posterior ventrolateral ridge and presumably forms the bed nuclei of the stria terminalis and the anterior commissure. On E15, the early differentiating cells in these anlagen fuse in the same region where the anterior commissure will cross on E17. On E16 and E17, a prominent subependymal zone develops in the anterior septal region and presumably gives rise to the nucleus accumbens. A quantitative analysis was made of three cell zones (neuroepithelium, subependymal zone, differentiating cell zone) at coronal levels through the developing nucleus accumbens and the nucleus of the diagonal band (anterior level) and the medial and lateral septal nuclei (middle and posterior levels). To accurately locate regions of primitive mitotic and migratory cells within the zones at each level, the number of cells surviving a single exposure to 200 R x-rays in embryonic brains (E15 to E22) were compared with controls. Each zone responded differently to x-ray insult. The radiosensitivity of the neuroepithelium decreases significantly after E19; the subependymal zone is highly radiosensitive throughout; the differentiating cell zone is radioresistant throughout. The significance of these findings is discussed in the light of the autoradiographic determination of the time of formation of septal neurons.

• Research Organization: Purdue Univ., West Lafayette, IN
• OSTI ID: 7097764
• Journal Information: J. Comp. Neurol.; (United States), Journal Name: J. Comp. Neurol.; (United States) Vol. 183:1; ISSN JCNEA
• Country of Publication: United States
• Language: English

Related Subjects

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560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CELL DIFFERENTIATION
CENTRAL NERVOUS SYSTEM
ELECTROMAGNETIC RADIATION
EMBRYOS
IONIZING RADIATIONS
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
ONTOGENESIS
ORGANS
RADIATIONS
RADIOSENSITIVITY
RATS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
VERTEBRATES
X RADIATION