Teratogenic assessment of three methylated hydrazine derivatives in the rat

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530486· OSTI ID:7096454

Keller, W C; Olson, C T; Back, K C

The embryotoxicity and teratogenicity of methylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine were investigated with pregnant Fischer-344 rats. The compounds were administered ip on d 6-15 of pregnancy. A dose-dependent reduction in maternal weight gains occurred for all three compounds. A dose-related teratogenic effect did not occur for any of the three compounds. Embryotoxicity, manifested as reduced 20-d fetal weights, occurred only in the 1,1-dimethylhydrazine and 1,2-dimethylhydrazine high-dose treatement groups. The results indicate that none of the three methylated hydrazine derivatives are selectively embryotoxic or teratogenic in the rat.

• Research Organization: Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH
• OSTI ID: 7096454
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:1; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHEMICAL REACTIONS
DOSE-RESPONSE RELATIONSHIPS
FETUSES
HYDRAZINE
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
METHYLATION
NITROGEN COMPOUNDS
RATS
RODENTS
SCREENING
TERATOGEN SCREENING
VERTEBRATES
WEIGHT