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Acute toxicity of the vapors of some methylated hydrazine derivatives

Journal Article · · AMA Arch. Ind. Health; (United States)
OSTI ID:6402840
; ; ; ;
Methylhydrazine, asym-dimethylhydrazine, and sym-dimethylhydrazine vapors are similar to hydrazine in that they are respiratory irritants an;d convulsants on acute exposure. In addition to causing respiratory distress and convulsions, methylhydrazine vapor was found to produce hemolysis and elevated temperatures in exposed dogs. Methylhydrazine was the most toxic of the vapors tested, and hydrazine the least toxic. The higher volatility of asym-dimethylhydrazine indicates that the hazard of this vapor is similar to methylhydrazine. However, the hemolytic properties of methylhydrazine indicate that this vapor has a greater sublethal hazard. Preliminary data on sym-dimethylhydrazine suggest that this vapor has a toxicity and vapor hazard that is less than methylhydrazine and asym-dimethylhydrazine but greater than hydrazine. The odors of hydrazine, methylhydrazine, and asym-dimethylhydrazine were usually described by human subjects as ammoniacal, fishy, or amine-like. The odor of these vapors appears to offer adequate warning of acute exposure to dangerous aspirations. 16 references, 2 figures, 7 tables.
OSTI ID:
6402840
Journal Information:
AMA Arch. Ind. Health; (United States), Journal Name: AMA Arch. Ind. Health; (United States) Vol. 12; ISSN AMIHA
Country of Publication:
United States
Language:
English

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Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
DATA
DOGS
EXPERIMENTAL DATA
FLUIDS
GASES
HAZARDS
HEALTH HAZARDS
HYDRAZINE
INFORMATION
MAMMALS
MAN
NITROGEN COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
TOXICITY
VAPORS
VERTEBRATES