Exposures of human volunteers to a controlled atmospheric mixture of ozone, sulfur dioxide and sulfuric acid

Journal Article · Wed Dec 31 23:00:00 EST 1980 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668191419361· OSTI ID:7095977

Kleinman, M T; Bailey, R M; Chang, Y T.C.; Clark, K W; Jones, M P; Linn, W S; Hackney, J D

Nineteen human volunteers with normal pulmonary function and no history of asthma were exposed on two separate days to clean air and to an atmospheric mixture containing ozone (O/sub 3/), 0.37 ppM, sulfur dioxide (SO/sub 2/), 0.37 ppM, and sulfuric acid aerosol (H/sub 2/SO/sub 4/), 100 ..mu..g/m/sup 3/. Subjects were exposed under carefully controlled conditions for two hours. During this period, the subjects alternately exercised for 15 minutes, at a level calculated to double minute ventilation, and rested for 15 minutes. The experimental goal was to detrmine whether the presence of the copollutants, H/sub 2/SO/sub 4/ and SO/sub 2/, would significantly enhance the irritant potential of ozone, or cause decrements in pulmonary function on the order of 10 to 20 percent. Statistical analysis of the group averaged data suggest that the mixture may have been slightly more irritating to the subjects than was O/sub 3/ alone. A large percentage of the subjects exhibited small decrements in pulmonary function. The group averaged FEV/sub 1/ /sub 0/ (forced expiratory volume in one second) on the exposure day was depressed 3.7 percent from the control value. One might expect O/sub 3/ alone to depress FEV/sub 1/ /sub 0/ by about 2.8 percent under similar exposure conditions.

• Research Organization: Univ. of Southern California, Downey
• OSTI ID: 7095977
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 42:1; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COLLOIDS
DATA
DATA COMPILATION
DISPERSIONS
HYDROGEN COMPOUNDS
INFORMATION
INHALATION
INHIBITION
INORGANIC ACIDS
INTAKE
LUNGS
MAMMALS
MAN
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PRIMATES
RESPIRATORY SYSTEM
SOLS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SULFURIC ACID
SYNERGISM
TRACE AMOUNTS
VERTEBRATES