Effect of long-term propranolol administration on specific binding of /sup 3/H-WB-4101 with rat mesenteric vascular membranes
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The aim of this investigation was, first, to study the affinity of certain beta-adrenoblockers for specific binding sites of /sup 3/H-WB-4101 (identifiable as alpha-adrenoreceptors) of brain membranes and, second, to study the characteristics of these same receptors in membranes of mesenteric vessels of rats during long-term administration of propranolol. Isotherms of specific binding, because of the limited quantity of vascular membranes, were determined by the use of three concentrations of /sup 3/H-WB-4101: 0.1, 0.5, and 1.0 nM. It is shown that some beta-adrenoblockers have weak affinity for alpha-adrenoreceptors of brain synaptic membranes exhibited only when these compounds are present in relatively high concentrations. It is also shown that administration of propranolol for 15 days led to a significant decrease in affinity of the alpha-adrenorecptors for their specific antagonist WB-4101.
- Research Organization:
- Institute of Pharmacology, Acad. of Med. Sci., Moscow
- OSTI ID:
- 7091478
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:7; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALCOHOLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHRONIC INTAKE
DISEASES
DRUGS
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
INHIBITION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
MESENTERY
NERVE CELLS
NERVOUS SYSTEM
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PROPANOLS
PROTEINS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RODENTS
SEROUS MEMBRANES
SOMATIC CELLS
STEROID HORMONES
SYMPTOMS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALCOHOLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHRONIC INTAKE
DISEASES
DRUGS
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
INHIBITION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
MESENTERY
NERVE CELLS
NERVOUS SYSTEM
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PROPANOLS
PROTEINS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RODENTS
SEROUS MEMBRANES
SOMATIC CELLS
STEROID HORMONES
SYMPTOMS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES