Effect of chronic psychogenic stress on characteristics of some rat brain synaptic membrane receptors
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6999701
This paper studies characteristics of alpha- and beta-adrenoreceptors, and imipramine and bensodiazepine receptors in brain synaptic membranes of rats after exposure to combined stress for 15 days by a modified Hecht's method. Before the experiment the suspension was thawed and centrifuged. Specific binding of tritium-WB-4101 (30 Ci/mmole), tritium-dihydroalprenolol, tritium-flunitrazepam, and tritium-imipramine was carried out by known methods with certain modifications. The results suggest that pathology of behavior in rats observed in the model may be classed as a depressive-like state rather than a neurosis-like state, and the model itself may be more appropriate for the study of the mechanisms of action of compounds with marked tranquilizing activity.
- Research Organization:
- Research Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow
- OSTI ID:
- 6999701
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:9; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550101 -- Behavioral Biology-- Tracer Techniques
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTIDEPRESSANTS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC EXPOSURE
DRUGS
ELECTRIC SHOCK
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PSYCHOTROPIC DRUGS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RETENTION
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTIDEPRESSANTS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC EXPOSURE
DRUGS
ELECTRIC SHOCK
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PSYCHOTROPIC DRUGS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RETENTION
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES