Experimental study of the antimutagenic properties of 5-methylresorcinol

Journal Article · Sun Dec 01 04:00:00 EST 1985 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00839314· OSTI ID:7091460

Pashin, Y V; Bakhitova, L M; Bentken, T I

The antimutagenic activity of 5-MR during the action of benz(a) pyrene (BP), a typical environmental pollutant, and also of gamma-rays, as a result of whose action products of free-radical oxidation of hydroperoxides accumulate, was studied in vivo. Chinese hamsters were used in the experiments and the animals were irradiated on the GUPOS apparatus with /sup 137/Cs source of gamma-rays at 0 degrees C, with a total dose of 75 or 150 rads. 5-MR was found to be an antioxidant with antimutagenic properties. The effect of 5-MR on the number of micronuclei induced in polychromatophilic erythrocytes of mouse bone marrow by BP and gamma-rays is shown.

• Research Organization: N.I. Vavilov Institute of General Genetics, Acad. of Sci.
• OSTI ID: 7091460
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:7; ISSN BEXBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ANTIOXIDANTS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONDENSED AROMATICS
DEVELOPERS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
EXTERNAL IRRADIATION
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
HEMATOPOIETIC SYSTEM
HYDROCARBONS
HYDROXY COMPOUNDS
INHIBITION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MUTAGENESIS
MUTAGENS
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIATION EFFECTS
RADIATIONS
RESORCINOL
RODENTS
SURVIVAL CURVES
TISSUES
VERTEBRATES