Radiation-induced enzyme efflux from rat heart: sedentary animals. [Gamma radiation, lactate dehydrogenase, creative kinase, glutamate oxaloacetate transaminase]
Journal Article
·
· Recent Adv. Stud. Card. Struct. Metab.; (United States)
OSTI ID:7091016
Serum levels of lactate dehydrogenase, creatine kinase, and glutamate oxaloacetate transaminase show initial elevations within 12 hr of exposure to 2,000 rads of ..gamma..-radiation to the thoracic region of rats. Significant decreases in heart muscle homogenate levels of these enzymes parallel initial elevations in the serum and may suggest that enhanced leakage of enzymes is a consequence of radiation injury to heart muscle. Insignificant alterations in mitochondrial glutamate oxaloacetate transaminase levels after exposure indicate that in vivo injury to the mitochondria from therapeutic levels of ..gamma..-radiation is questionable. The results support the contention that ionizing radiation instigates alterations in the dynamic permeability of membranes, allowing leakage of biologically active material out of the injured cell.
- Research Organization:
- Simon Fraser Univ., Burnaby, British Columbia, Can.
- OSTI ID:
- 7091016
- Journal Information:
- Recent Adv. Stud. Card. Struct. Metab.; (United States), Journal Name: Recent Adv. Stud. Card. Struct. Metab.; (United States) Vol. 9; ISSN RCSMC
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:4223150
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
AMINOTRANSFERASES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CHEST
DEHYDROGENASES
ELECTROMAGNETIC RADIATION
ENZYMES
GAMMA RADIATION
HEART
IONIZING RADIATIONS
LACTATE DEHYDROGENASE
MAMMALS
METABOLISM
MITOCHONDRIA
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PERMEABILITY
PHOSPHOTRANSFERASES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
TRANSFERASES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
AMINOTRANSFERASES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CHEST
DEHYDROGENASES
ELECTROMAGNETIC RADIATION
ENZYMES
GAMMA RADIATION
HEART
IONIZING RADIATIONS
LACTATE DEHYDROGENASE
MAMMALS
METABOLISM
MITOCHONDRIA
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PERMEABILITY
PHOSPHOTRANSFERASES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
TRANSFERASES
VERTEBRATES