Clinical ventilation imaging with /sup 113m/In aerosol: a comparison with /sup 81m/Kr

Journal Article · Thu Apr 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:7089280

Fazio, F; Wollmer, P; Lavender, J P; Barr, M M

Following routine ventilation (/sup 81m/Kr)/perfusion (/sup 99m/Tc) scanning, we obtained aerosol ventilation scans using a solution of /sup 113m/In albumin and a settling-bag system. The large-volume settling bag reduces deposition of particles in the large airway by removing large droplets. The patient inhales the aerosol with 5-10 min of tidal breathing, then lung scans are obtained on a gamma camera. The energy of /sup 113m/In allows the ventilation scanning to be performed after /sup 99m/Tc perfusion scanning. Semiquantitative scoring of regional ventilation showed a close correlation (r . 0.97) between /sup 81m/Kr and /sup 113m/In aerosol ventilation scans. The aerosol technique gave a slight underestimation of ventilation compared with /sup 81m/Kr. This is explained by a slightly reduced penetration of particles to the periphery of the lung in patients with severe obstructive airways disease. In all cases, however, the aerosol did visualize all ventilated regions. The results indicate that this readily available aerosol technique can be useful for clinical ventilation imaging in multiple views.

• Research Organization: Hammersmith Hospital, London, UK
• OSTI ID: 7089280
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INDIUM 113
INDIUM ISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SOLS
STABLE ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES