Clinical assessment of a commercial aerosol delivery system for ventilation scanning by comparison with KR-81m

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6781072

Wollmer, P; Eriksson, L; Andersson, A C

Radioactive aerosols offer a means for steady state ventilation scanning in multiple views. The clinical use of radioaerosol techniques has been hampered by the lack of delivery systems producing sufficiently small particles. If the aerosol contains large particles, heavy deposition occurs in major airways, especially in patients with airways disease. The authors have assessed a new, commercial aerosol delivery system (Syntevent) by comparison with Kr-81m ventilation scanning in 23 patients with airways obstruction. An indirect comparison was also made with a settling bad technique. Ventilation scans in four projections were obtained during continuous inhalation of Kr-81m. Subsequently, the patient inhaled an aerosol labelled with In-113m from the Syntevent system, and aerosol ventilation scans were obtained in the same projections. Spirometry was performed to establish the degree of airways obstruction. The aerosol delineated the ventilated regions of the lungs adequately in all the patients. Deposition of aerosol in larger airways was seen in a few patients only, and this did not impede the interpretation of the scintigram. A quantitative analysis of the penetration of the aerosol to the periphery of the lung failed to demonstrate any significant correlation between particle penetration and airways obstruction. Aerosol penetration was significantly greater (p<0.001) with the Syntevent system than with a settling bag technique.

• Research Organization: Depts. of Clinical Physiology and Lung Medicine, Univ. of Lund, Lund
• OSTI ID: 6781072
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOL GENERATORS
AEROSOLS
BETA DECAY RADIOISOTOPES
BODY
COLLOIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DEPOSITION
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INDIUM 111
INDIUM ISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLING
LUNGS
MINUTES LIVING RADIOISOTOPES
NOZZLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARTICLES
PARTICULATES
PERFORMANCE TESTING
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SOLS
STEADY-STATE CONDITIONS
TESTING
USES
VENTILATION
YEARS LIVING RADIOISOTOPES