Effect of perfusate hematocrit on urea permeability-surface area in isolated dog lung
Seven dog lower left lung lobes were statically inflated and perfused at a constant rate for each lobe with a perfusate in which the hematocrit was altered over a wide range. The permeability-surface area of urea was calculated from multiple indicator dilution curves using two separate injectates for each hematocrit level. One injectate contained only /sup 125/I-albumin as the vascular reference tracer and the other contained both /sup 51/Cr-erythrocytes and /sup 125/I-albumin as the vascular reference tracers; both contained (/sup 14/C)urea as the permeating tracer. The results strongly indicate that the phenomenon of erythrocyte trapping of urea does not affect the calculation of urea permeability-surface area product provided the appropriate albumin-erythrocyte composite reference tracer is utilized in its calculation.
- Research Organization:
- Vanderbilt Univ. School of Medicine, Nashville, TN
- OSTI ID:
- 7085606
- Journal Information:
- J. Appl. Physiol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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UREA
PERMEABILITY
ALBUMINS
BLOOD COUNT
CARBON 14 COMPOUNDS
CHROMIUM 51
DOGS
ERYTHROCYTES
IN VITRO
IODINE 125
LABELLED COMPOUNDS
LUNGS
PERFUSED ORGANS
RESPONSE MODIFYING FACTORS
SURFACE AREA
SURFACE PROPERTIES
TRACER TECHNIQUES
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONIC ACID DERIVATIVES
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques