Effect of ozone on human cellular and humoral immunity: characterization of T and B lymphocytes by rosette formation

Journal Article · Wed Feb 01 04:00:00 EST 1978 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(78)90079-8· OSTI ID:7084849

Savino, A ^[1]; Peterson, M L; House, D; Turner, A G; Jeffries, H E; Baker, R

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1. Environmental Protection Agency, Chapel Hill, NC

Eight healthy male subjects were exposed to 784 ..mu..g/m/sup 3/ (0.4 ppM) of ozone for 4 hours in an environmentally controlled exposure chamber. Peripheral blood samples were taken before and after air and ozone exposures and again at 72 hours and 2 weeks. These blood samples were examined for the percentages of rosette-forming T and B lymphocytes. No statistically significant depressions in T-lymphocyte rosette formation with sheep erythrocytes were found following exposure to air or ozone. The ability of B lymphocytes to form rosettes with sensitized human erythocytes was depressed following ozone exposure. These results suggest that surface receptors and/or the cell membranes of peripheral blood B lymphocytes may be temporarily altered following short-term exposure to ozone.

• OSTI ID: 7084849
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 15:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CONNECTIVE TISSUE CELLS
ERYTHROCYTES
EXPOSURE CHAMBERS
IMMUNITY
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MEMBRANES
OZONE
PRIMATES
SOMATIC CELLS
VERTEBRATES