Long-term loss of radium in 63 subjects first exposed at ages 6 to 46

Conference · Wed Jan 01 04:00:00 EST 1986

OSTI ID:7082537

Keane, A T; Schlenker, R A

The absorbed dose to bone following the deposition of radium in the skeleton is principally determined by its long-term rate of clearance. In mice, rats, and dogs injected with alkaline-earth radionuclides at various ages between puberty and young adulthood, a negative correlation was observed between the age at injection and the skeletal uptake of the radionuclide and, at short times after injection, a positive correlation was observed between the age at injection and the fraction of the contemporary body content of the radionuclide excreted per unit of time, whereas at long times after injection the fractional clearance rate was found to be largely independent of the age at injection. Age-dependent models of radium retention proposed for man conform to the metabolic observations in animals in their assumption that at long times after intake the fraction of the contemporary body content of radium excreted per unit of time is independent of the age at intake. In this paper, we investigate whether this assumption is supported by the data on the long-term retention of radium in radium-exposed persons.

• Research Organization: Argonne National Lab., IL (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 7082537
• Report Number(s): CONF-861123-5; ON: DE87004689
• Country of Publication: United States
• Language: English

Related Subjects

560151 -- Radiation Effects on Animals-- Man
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
CLEARANCE
DIAL PAINTERS
EVEN-EVEN NUCLEI
EXCRETION
HEAVY NUCLEI
ISOTOPES
MATHEMATICAL MODELS
NUCLEI
PERSONNEL
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIUM 226
RADIUM ISOTOPES
SEX DEPENDENCE
YEARS LIVING RADIOISOTOPES