Prostatic acid phosphatase by radioimmunoassay
Journal Article
·
· J. Am. Med. Assoc.; (United States)
Prostatic acid phosphatase values in 98 patients with prostatic carcinoma were measured by a commmercial radioimmunoassay (RIA) and by enzymatic assay. Forty-three carcinomas were staged by rigorous pathological criteria. Patients (N = 129) with benign prostatic hyperplasia were the control group. At 94% specificity, sensitivities of the RIA vs the enzymatic assay for clinically staged patients were as follows: stage A, 22% vs 6%; B, 29% vs 10%; C, 52% vs 38%; and D, 87% vs 80%. However, none of the seven patients with pathological stage A and B disease had a positive test result, and we suggest that variability in staging criteria accounts for the discrepant sensitivity claims reported. Prostatic acid phosphatase RIA should not be used for screening but as an adjunct for staging known prostatic carcinoma.
- Research Organization:
- Swedish Hospital Medical Center, Seattle, WA
- OSTI ID:
- 7079804
- Journal Information:
- J. Am. Med. Assoc.; (United States), Journal Name: J. Am. Med. Assoc.; (United States) Vol. 244:18; ISSN JAMAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACID PHOSPHATASE
BODY
CARCINOMAS
COMPARATIVE EVALUATIONS
DIAGNOSIS
DISEASES
ENZYME ACTIVITY
ENZYMES
ESTERASES
GLANDS
HYDROLASES
ISOTOPE APPLICATIONS
MALE GENITALS
NEOPLASMS
ORGANS
PATHOLOGY
PATIENTS
PHOSPHATASES
PROSTATE
RADIOASSAY
RADIOIMMUNOASSAY
SENSITIVITY
TRACER TECHNIQUES
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACID PHOSPHATASE
BODY
CARCINOMAS
COMPARATIVE EVALUATIONS
DIAGNOSIS
DISEASES
ENZYME ACTIVITY
ENZYMES
ESTERASES
GLANDS
HYDROLASES
ISOTOPE APPLICATIONS
MALE GENITALS
NEOPLASMS
ORGANS
PATHOLOGY
PATIENTS
PHOSPHATASES
PROSTATE
RADIOASSAY
RADIOIMMUNOASSAY
SENSITIVITY
TRACER TECHNIQUES