A critical evaluation of a specific radioimmunoassay for prostatic acid phosphatase

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19821101)50:9<1847::AID-CNCR2820500931>3.0.CO;2-P· OSTI ID:5686041

Goldenberg, S L; Silver, H K; Sullivan, L D; Morse, M J; Archibald, E L

A radioimmunoassay (RIA) method for acid phosphatase detection was compared to a standard enzyme assay using sera from 210 normal volunteers and 285 patients with prostatic disease. Statistical and clinical comparisons were made between defined subgroups. All 55 normal females had RIA detectable serum acid phosphatase, implying that this assay cannot be entirely specific for enzyme of prostatic origin. Urinary catheterization did not affect acid phosphatase levels. In all stages of carcinoma there were more acid phosphatase elevations by the RIA method than enzyme method, but neither assay could differentiate intercapsular cancer from benign prostatic hyperplasia. A small number of patients with biopsy proven negative nodules had marginally elevated values, suggesting an obligation for closer follow-up. The RIA method may be superior for monitoring patients with more advanced malignancy. Additional practical advantages of the RIA include relative simplicity and elimination of the special serum handling required for the enzyme assay.

• Research Organization: Univ. of British Columbia, Canada
• OSTI ID: 5686041
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:9; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACID PHOSPHATASE
BLOOD SERUM
BODY
CARCINOMAS
DISEASES
ENZYMES
ESTERASES
EVALUATION
GLANDS
HYDROLASES
HYPERTROPHY
ISOTOPE APPLICATIONS
MALE GENITALS
NEOPLASMS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PHOSPHATASES
PROSTATE
RADIOASSAY
RADIOIMMUNOASSAY
TRACER TECHNIQUES