2,3,7,8-tetrachlorodibenzo-p-dioxin: potent anticarcinogenic activity in CD-1 mice

Journal Article · Wed Feb 14 04:00:00 EST 1979 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(79)91752-2· OSTI ID:7077753

DiGiovanni, J; Berry, D L; Juchau, M R; Slaga, T J

Topical pretreatment with non-toxic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant formed in the commercial synthesis of the herbicide, 2,4,5-trichlorophenoxyacetic acid, strongly inhibited the initiation of skin tumors by 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene in female CD-1 mice. 2,3,7,8-tetrachlorodibenzo-p-dioxin also produced marked induction of epidermal monooxygenase enzymes functional in the conversion of 7,12-dimethylbenz(a)anthracene to a variety of hydroxylated products. The time course of anticarcinogenic effects resulting from pretreatment with the dioxin correlated with the magnitude of induction as well as with a significant reduction in the quantity of 7,12-dimethylbenz(a)anthracene metabolites covalently bound in vivo to epidermal DNA and RNA but not protein.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 7077753
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 86:3; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL CONSTITUENTS
CONDENSED AROMATICS
DIMETHYLBENZANTHRACENE
DIOXIN
DISEASES
DNA
ENZYMES
HERBICIDES
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
IN VIVO
INHIBITION
MAMMALS
MICE
MICROSOMES
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PATHOGENESIS
PESTICIDES
RNA
RODENTS
SKIN
VERTEBRATES