Tumor-initiating ability of 2,3,7,8-tetrachlorodibenzo-p-Dioxin (TCDD) and Arochlor 1254 in the two-stage system of mouse skin carcinogenesis

Journal Article · Tue Nov 01 04:00:00 EST 1977 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01684000· OSTI ID:7055488

DiGiovanni, J; Viaje, A; Berry, D L; Slaga, T J; Juchau, M R

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) a contaminant of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)- and Arochlor 1254 a PCB used as a plasticizer in industry were tested for effects in the two stage system of mouse skin carcinogenesis. Both were found to be weak tumor initiators, and only slightly modify the response of a known carcinogen in this system.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 7055488
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 18:5; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
CARCINOGENESIS
CARCINOGENS
DISEASES
HERBICIDES
MAMMALS
MICE
NEOPLASMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
PESTICIDES
RODENTS
TOXICITY
VERTEBRATES