Fundamental studies with a monodisperse aerosol-based liquid chromatography/mass spectrometry interface (MAGIC-LC/MS): Progress report, September 1, 1985-August 31, 1988

Technical Report · Sun May 01 04:00:00 EDT 1988

OSTI ID:7077399

Browner, R F

Technical advances have been made through a number of careful and detailed studies of fundamental processes occurring within the interface. These have led to great improvements in the performance of the interface, many of which are detailed below. Of particular importance has been an improvement in detection capabilities, allowing full-scan (40--400 daltons) electron impact mass spectra to be obtained with only approximately 5 ng of material injected on column. Selected ion monitoring gives detection limits in the range of 100 pg. These figures are particularly noteworthy because they represent values within a factor of 3 of the lowest detection limits possible with the same instrument when used in a GC/MS mode. The full range of compound types accessible with the MAGIC-LC/MS interface has not been fully investigated. In general terms, all compounds which are known to be capable of generating EI and CI spectra and which have been tried with the interface have generated good quality spectra. These include carbamate and triazine pesticides, phenyl urea herbicides, polynuclear aromatic hydrocarbons, plant alkaloids, antioxidants and EPA Appendix 8 compounds. Compounds known not to generate EI spectra, such as simple sugars and certain azo dyes, predictably do not generate spectra with the current system. The primary mode of ion formation appears to be through a flash vaporization step in the ion source, followed by EI or CI ionization, as selected. It is possible to generate good searchable EI spectra with strong molecular ions even for quite involatile species. An example is provided by reserpine, with a molecular weight of 608 daltons, which generates a searchable EI spectrum with a strong molecular ion at m/z 608. 11 refs.

• Research Organization: Georgia Inst. of Tech., Atlanta (USA). School of Chemistry
• DOE Contract Number: FG05-85ER13435
• OSTI ID: 7077399
• Report Number(s): DOE/ER/13435-3; ON: DE88011628
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
AEROSOLS
CHROMATOGRAPHY
COLLOIDS
DESIGN
DISPERSIONS
DOCUMENT TYPES
EFFICIENCY
INTERFACES
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTROMETERS
MEASURING INSTRUMENTS
PROGRESS REPORT
SEPARATION PROCESSES
SOLS
SOLVENTS
SPECTRA
SPECTROMETERS