Fundamental studies with a monodisperse aerosol-based liquid chromatography/mass spectrometry interface (MAGIC-LC/MS)

Technical Report · Mon May 01 04:00:00 EDT 1989

DOI:https://doi.org/10.2172/6963245· OSTI ID:6963245

Browner, R F

A number of accomplishments have been made during the term of this grant. These include both technical aspects of the project, and developments associated with commercial development of the MAGIC- LC/MS interface. Technical advances have been made through a number of detailed studies of fundamental processes occurring with the interface. These have led to substantial improvements in the performance of the interface many of which are detailed below. Of particular importance has been a major improvement in detection capabilities. At beginning of this grant period, sensitivity for many compounds was in the high {mu}g to low mg range. Presently, full-scan (40-400 daltons) electron impacts mass spectra may be obtained for many compounds with typically 10--50 ng of material injected on column. Selected ion monitoring gives detection limits in the range of 100--1000 pg. These figures are particularly noteworthy because they represent values which fall between 3--10x the lowest detection limits possible with the same instrument when used in a GC/MS mode.

• Research Organization: Georgia Inst. of Tech., Atlanta, GA (USA). School of Chemistry
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG05-85ER13435
• OSTI ID: 6963245
• Report Number(s): DOE/ER/13435-4; ON: DE90010667
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
AEROSOLS
CHROMATOGRAPHY
COLLOIDS
DESIGN
DISPERSIONS
DOCUMENT TYPES
EQUIPMENT INTERFACES
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTROMETERS
MEASURING INSTRUMENTS
PROGRESS REPORT
SEPARATION PROCESSES
SOLS
SPECTROMETERS
TEMPERATURE EFFECTS