Electron spin-resonance of x-irradiated nucleic acid base pairs, 1-methyl cytosine:5-fluorouracil at 300 K

Journal Article · Tue Jan 31 23:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574815· OSTI ID:7075846

Close, D M; Farley, R A; Bernhard, W A

Three free radicals have been detected in single crystals of a molecular complex between 1-methylcytosine (1 MeC) and 5-fluorouracil (5 FU) x-irradiated and observed by ESR at 77 K. One of these (Radical I), formed by H abstraction from N(1) of 5 FU, disappears when the crystal is warmed to 220 K. The other two radicals are stable at room temperature. Radical II is formed by H addition to C(6) of 5 FU. Radical III has been tentatively assigned to a radical formed by H addition to the oxygen on C(4) of 5 FU. The structural analysis of these two stable room-temperature radicals and the resulting implication that free radical damage may be transferred from 1 MeC to 5 FU are discussed.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 7075846
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
CHEMICAL RADIATION EFFECTS
CHEMISTRY
CRYSTALS
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
FLUOROURACILS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
MAGNETIC RESONANCE
MEDIUM TEMPERATURE
MONOCRYSTALS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOINDUCTION
RESONANCE
STRUCTURAL CHEMICAL ANALYSIS
URACILS
X RADIATION