Electron spin-resonance of x-irradiated nucleic acid base pairs, 1-methyl cytosine:5-fluorouracil at 300 K

Journal Article · Wed Feb 01 00:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574815· OSTI ID:7075846

Close, D M; Farley, R A; Bernhard, W A

Three free radicals have been detected in single crystals of a molecular complex between 1-methylcytosine (1 MeC) and 5-fluorouracil (5 FU) x-irradiated and observed by ESR at 77 K. One of these (Radical I), formed by H abstraction from N(1) of 5 FU, disappears when the crystal is warmed to 220 K. The other two radicals are stable at room temperature. Radical II is formed by H addition to C(6) of 5 FU. Radical III has been tentatively assigned to a radical formed by H addition to the oxygen on C(4) of 5 FU. The structural analysis of these two stable room-temperature radicals and the resulting implication that free radical damage may be transferred from 1 MeC to 5 FU are discussed.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 7075846
• Journal Information: Radiat. Res.; (United States), Vol. 73:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FLUOROURACILS
CHEMICAL RADIATION EFFECTS
PYRIMIDINES
RADICALS
RADIOINDUCTION
STRUCTURAL CHEMICAL ANALYSIS
ELECTRON SPIN RESONANCE
IRRADIATION
MEDIUM TEMPERATURE
MONOCRYSTALS
X RADIATION
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
CHEMISTRY
CRYSTALS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MAGNETIC RESONANCE
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RESONANCE
URACILS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)