Estimation of breast doses and breast cancer risk associated with repeated fluoroscopic chest examinations of women with tuberculosis
A methodology is presented to estimate cumulative breast dose and breast cancer risk for women exposed to repeated fluoroscopic chest examinations during air collapse therapy for pulmonary tuberculosis. Medical record abstraction, physician interview, patient contact, machine exposure measurements, and absorbed dose computations were combined to estimate average breast doses for 1047 Massachusetts women who were treated between 1930 and 1954. The methodology presented considers breast size and composition, patient orientation, x-ray field size and location, beam quality, type of examination, machine exposure rate, and exposure time during fluoroscopic examinations. The best estimate for the risk of radiation-induced cancer for the women living longer than 10 years after initial fluoroscopic exposure is 6.2 excess breast cancers per million woman-year-rad with 90% confidence limits of 2.8 and 10.7 cancers/10/sup 6/ WY-rad. When breast cancer risk is considered as a function of absorbed dose in the breast, instead of as a function of the number of fluoroscopic examinations, a linear dose--response relationship over the range of estimated doses is consistent with the data. However, because of the uncertainty due to small-sample variability and because of the wide range of assumptions regarding certain fluoroscopy conditions, other dose--response relationships are compatible with the data.
- Research Organization:
- Harvard School of Public Health, Boston
- OSTI ID:
- 7075708
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
BODY AREAS
CARCINOGENESIS
CHEST
DELAYED RADIATION EFFECTS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
FEMALES
FLUOROSCOPY
GLANDS
HAZARDS
HEALTH HAZARDS
INFECTIOUS DISEASES
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOGENESIS
PATIENTS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
TUBERCULOSIS
VERTEBRATES
WOMEN
X RADIATION