Cancer mortality in women after repeated fluoroscopic examinations of the chest

Journal Article · Fri May 01 04:00:00 EDT 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5578007

Boice, J D; Monson, R R; Rosenstein, M

Among 1,047 women fluoroscopically examined in average of 102 times during pneumothorax therapy for tuberculosis and followed up to 45 years (average . 27 yr), no increase in the total number of cancer deaths occurred when these women were compared to 717 women who received other treatments (relative risk (RR) . 0.8). However, elevated risks of mortality from stomach cancer (RR . 2.3), rectal cancer (RR . 3.8), breast cancer (RR . 1.2), lung cancer (RR . 1.8), and leukemia (RR . 1.2) were observed, but none was statistically significant and all were based on very small numbers of deaths. These increases were balanced by decreases of genital cancer (RR . 0.2), pancreatic cancer (RR . 0.9), lymphoma (RR . 0.6), and all other cancers (RR . 0.1). Average cumulative absorbed doses were 110 rads for the lungs, 33 rads for the trunk, 13 rads for the active bone marrow, and 7 rads for the stomach. The following upper levels of excess risk could be excluded with 95% confidence: 3.5 deaths/10(6) woman-year (WY)-rad for lung cancer, 4.8 deaths/10(6) WY-rad for lymphoma, and 12 deaths/10(6) WY-rad for leukemia. These findings indicated that the carcinogenic effect of multiple low-dose X-ray exposures was not greater than that currently assumed.

• OSTI ID: 5578007
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 66:5; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
550900 -- Pathology
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
BODY AREAS
BONE MARROW
CARCINOGENESIS
CHEST
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
FEMALES
FLUOROSCOPY
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
INFECTIOUS DISEASES
IONIZING RADIATIONS
LUNGS
MAMMALS
MAN
MEDICINE
MORTALITY
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOGENESIS
PATIENTS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RESPIRATORY SYSTEM
RISK ASSESSMENT
SIDE EFFECTS
STOMACH
TISSUES
TUBERCULOSIS
VERTEBRATES
WOMEN
X RADIATION