Bone cancer among female radium dial workers. Latency periods and incidence rates by time after exposure: brief communication

Journal Article · Sun Jan 01 04:00:00 EST 1978 · J. Natl. Cancer Inst.; (United States)

OSTI ID:7075610

Polednak, A P

Bone cancer cases in 1250 women exposed to radium while working in the luminous watch-dial industry between 1913 and 1929 were analyzed for times of appearance (''latency periods'') and incidence rates over time after first exposure. The lowest radium intake dose associated with bone cancer, among 751 women whose intake doses had been determined, was 202.5 ..mu..Ci. Mean and median bone cancer latency periods tended to decline, but average survival among women without bone cancer also decreased with increasing intake level. Bone cancer incidence rates over time were compared in 2 intake-dose groups (200 to 749 and greater than or equal to 750 ..mu..Ci) by means of an actuarial method that takes competing risks into account. Incidence rates were consistently higher in the higher intake-dose group versus the lower dose group at each 5-year period after first exposure. The variability in the odds ratios across the time periods was not statistically significant, and the actuarial method provided little evidence for an effect of intake dose on the pattern of incidence rate over time. With the use of similar methods, no significant variability was evident in the relative odds of bone cancer over time after exposure between one group of women first exposed to radium at less than 18 years of age and another group exposed when 18 or more years old.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 7075610
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 60:1; ISSN JNCIA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DELAYED RADIATION EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
FEMALES
HEAVY NUCLEI
INGESTION
INTAKE
ISOTOPES
LATENCY PERIOD
MAMMALS
MAN
NEOPLASMS
NUCLEI
ORGANS
PATHOGENESIS
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIUM 226
RADIUM 228
RADIUM ISOTOPES
SKELETON
VERTEBRATES
WOMEN
YEARS LIVING RADIOISOTOPES