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Bone cancer among female radium dial workers. Latency periods and incidence rates by time after exposure: brief communication

Journal Article · · J. Natl. Cancer Inst.; (United States)
OSTI ID:6605962
Bone cancer cases in 1,250 women exposed to radium while working in the luminous watch-dial industry between 1913 and 1929 were analyzed for times of appearance (''latency periods'') and incidence rates over time after first exposure. The lowest radium intake dose associated with bone cancer, among 751 women whose intake doses had been determined, was 202.5 ..mu..Ci. Mean and median bone cancer latency periods tended to decline, but average survival among women without bone cancer also decreased with increasing intake level. Bone cancer incidence rates over time were compared in 2 intake-dose groups (200 to 749 and greater than or equal to 750 ..mu..Ci) by means of an actuarial method that takes competing risks into account. Incidence rates were consistently higher in the higher intake-dose group versus the lower dose group at each 5-year period after first exposure. The variability in the odds ratios across the time periods was not statistically significant, and the actuarial method provided little evidence for an effect of intake dose on the pattern of incidence rate over time. With the use of similar methods, no significant variability was evident in the relative odds of bone cancer over time after exposure between one group of women first exposed to radium at less than 18 years of age and another group exposed when 18 or more years old.
Research Organization:
Argonne National Lab., IL
OSTI ID:
6605962
Journal Information:
J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 60:1; ISSN JNCIA
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BONE CELLS
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FEMALES
INTAKE
MAMMALS
MAN
METALS
NEOPLASMS
OCCUPATIONAL DISEASES
ORGANS
PERSONNEL
PRIMATES
RADIUM
SKELETON
SOMATIC CELLS
SURVIVAL CURVES
VERTEBRATES
WOMEN