Rhenium(V) oxo complexes in chemistry and nuclear medicine

Thesis/Dissertation · Fri Jan 01 04:00:00 EST 1993

OSTI ID:7070115

Hansen, L

Part one. Structure-distribution relationships derived from rhenium structural models for [sup 99m]Tc and [sup 186/188]Re substrates of the renal anion transport system. [MO(MAG[sub 3])][sup 2[minus]] complexes (MAG[sub 3] = penta-anionic form of mercaptoacetyltriglycine (MAG[sub 3]H[sub 5]), M = [sup 99m]Tc, [sub 186,188]Re) have important applications in nuclear medicine but their renal clearance is not ideal. It is essential to determine the properties associated with efficient renal transport. The [MO(MAG[sub 3])][sup 2[minus]] complexes are dianionic with one charge associated with the metal and the second associated with a terminal CO[sub 2][sup [minus]]. Isomers of mercaptoacetylglyclyclaminobenzoic acid were synthesized to determine the effects of varying the position of the CO[sub 2][sup [minus]] on renal clearance. The CO[sub 2][sup [minus]] of MAG[sub 3]H[sub 5] was also replaced with SO[sub 3][sup [minus]] and PO[sub 3][sup 2[minus]] groups. The biological properties of [sup 99m]Tc complexes with the new ligands were determined and Re analogues were prepared as structural models. The results, along with preliminary molecular mechanics calculations, suggest that the oxo-carboxylate conformation, the oxo-carboxylate intramolecular distance, and steric interactions influence renal clearance. Part two. Re(V) oxo complexes with trimethylbenzimidazole, pyridine and lutidine ligands. The synthesis and characterization of Re[sub 2]OCl[sub 4] (Me[sub 3]Bzm)[sub 4] (26) (Me[sub 3] Bzm = 1,5,6--trimethylbenzimidazole) was investigated because (1) the structures and voltametry of [mu]-oxo-[Re[sub 2]O[sub 3]][sup 4+] complexes have been of recent interest; (2) Re can significantly affect the [sup 13]C NMR chemical shifts of coordinated ligands; and (3) Me[sub 3]Bzm is an important ligand in bioinorganic model complexes.

• Research Organization: Emory Univ., Atlanta, GA (United States)
• OSTI ID: 7070115
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400700 -- Radiochemistry & Nuclear Chemistry
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560160* -- Radionuclide Effects
Kinetics
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
CLEARANCE
COMPLEXES
CRYSTAL STRUCTURE
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EXCRETION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RADIOPHARMACEUTICALS
RENAL CLEARANCE
RHENIUM 186
RHENIUM 188
RHENIUM COMPLEXES
RHENIUM ISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TECHNETIUM
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
YEARS LIVING RADIOISOTOPES