HIPDM-SPECT in patients with medically intractable complex partial seizures. Ictal study

Journal Article · Fri Apr 01 04:00:00 EST 1988 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1988.00520280043014· OSTI ID:7069394

Lee, B I; Markand, O N; Wellman, H N; Siddiqui, A R; Park, H M; Mock, B; Worth, R M; Edwards, M K; Krepshaw, J

Both interictal and ictal N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3,propanediamine -single photon emission computed tomography (HIPDM-SPECT) were performed in 16 patients with medically intractable complex partial seizures. Ictal HIPDM-SPECT localized epileptic foci in 13 of 14 patients with unilateral temporal focus and provided confirmative evidence of epileptic focus in 11 patients by demonstrating maximally increased regional cerebral perfusion (rCP) in epileptic foci that had shown decreased rCP in a previous interictal study. Ictal HIPDM-SPECT in two patients with bitemporal foci showed more complicated patterns consisting of slightly increased rCP in bilateral multifocal regions. Ictal HIPDM-SPECT was particularly useful for investigating epileptic foci, and correlation with simultaneously recorded ictal electroencephalograms provided further insight for localizing epileptic foci.

• Research Organization: Indiana Univ. Medical Center, Indianapolis (USA)
• OSTI ID: 7069394
• Journal Information: Arch. Neurol.; (United States), Journal Name: Arch. Neurol.; (United States) Vol. 45:4; ISSN ARNEA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTROENCEPHALOGRAPHY
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NERVOUS SYSTEM DISEASES
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RADIOPHARMACEUTICALS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
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