Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Interactions between antitumor drugs and radiation in mammalian tumor cell lines: differential drug responses and mechanisms of resistance following fractionated X-irradiation or continuous drug exposure in vitro

Journal Article · · NCI Monogr.; (United States)
OSTI ID:7067652
; ; ; ; ;
Drug-resistant mammalian tumor cell lines have been derived by either fractionated x-irradiation treatment or exposure to vincristine or etoposide (VP-16-213) in vitro. Analyses of the patterns of responses expressed by these differently derived, resistant cell lines have shown variations in responses to a range of antitumor drugs depending upon the agent used to induce resistance. However, all treated cell lines express resistance to vincristine and, with one exception, to VP-16-213. Preliminary evidence has indicated that resistance to vincristine in drug-treated cells, but not x-irradiation-treated cells, is associated with impaired vincristine uptake; resistance to VP-16-213 in both differently derived, resistant sublines is associated with a reduction of VP-16-213-induced DNA single-strand breakage; and collateral sensitivity to cisplatin in x-irradiation-treated cells is associated with enhanced drug-induced DNA cross-linking. These data indicate that patterns of responses to antitumor drugs and the mechanisms associated with these altered responses differ depending upon the agent used to induce resistance.
Research Organization:
Imperial Cancer Research Fund, London (England)
OSTI ID:
7067652
Journal Information:
NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 6; ISSN NCIME
Country of Publication:
United States
Language:
English

Similar Records

Interactions between antitumor drugs and radiation in mammalian tumor cell lines: differential drug responses and mechanisms of resistance following fractionated X-irradiation or continuous drug exposure in vitro
Journal Article · Thu Dec 31 23:00:00 EST 1987 · NCI Monogr.; (United States) · OSTI ID:6992491
Preclinical screening for drugs effective against 5-fluorouracil-resistant cells with a murine L5178Y cell line in vitro
Journal Article · Mon Aug 01 00:00:00 EDT 1983 · JNCI, J. Natl. Cancer Inst.; (United States) · OSTI ID:5546796
Enhanced DNA repair and tolerance of DNA damage associated with resistance to cis-diammine-dichloroplatinum (II) after in vitro exposure of a human teratoma cell line to fractionated X-irradiation
Journal Article · Sun Jul 01 00:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA) · OSTI ID:6616416

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
CHEMICAL REACTIONS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERIZATION
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SENSITIVITY
STRAND BREAKS
TUMOR CELLS
VERTEBRATES
X RADIATION