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Interactions between antitumor drugs and radiation in mammalian tumor cell lines: differential drug responses and mechanisms of resistance following fractionated X-irradiation or continuous drug exposure in vitro

Journal Article · · NCI Monogr.; (United States)
OSTI ID:6992491
; ; ; ; ;
Drug-resistant mammalian tumor cell lines have been derived by either fractionated x-irradiation treatment or exposure to vincristine or etoposide (VP-16-213) in vitro. Analyses of the patterns of responses expressed by these differently derived, resistant cell lines have shown variations in responses to a range of antitumor drugs depending upon the agent used to induce resistance. However, all treated cell lines express resistance to vincristine and, with one exception, to VP-16-213. Preliminary evidence has indicated that resistance to vincristine in drug-treated cells, but not x-irradiation-treated cells, is associated with impaired vincristine uptake; resistance to VP-16-213 in both differently derived, resistant sublines is associated with a reduction of VP-16-213-induced DNA single-strand breakage; and collateral sensitivity to cisplatin in x-irradiation-treated cells is associated with enhanced drug-induced DNA cross-linking. These data indicate that patterns of responses to antitumor drugs and the mechanisms associated with these altered responses differ depending upon the agent used to induce resistance.
Research Organization:
Imperial Cancer Research Fund, London (England)
OSTI ID:
6992491
Journal Information:
NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 6; ISSN NCIME
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
CHEMICAL REACTIONS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERIZATION
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SENSITIVITY
STRAND BREAKS
TUMOR CELLS
VERTEBRATES
X RADIATION